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AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats
CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer
28(1):57-69
half-life (2
Preclinical Characterization of a Potent
LDN-57444 - Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor. CAS# 668467-91-2 Catalog No.:M60204-10S AC-55541 was stable to metabolismLDN 57444, CAS No. 668467 91 2, is a novel potent and selective inhibitor of ubiquitin C terminal hydrolase L1 (UCH L1) with IC50 ~0. 88 M. It has ~28 fold greater selectivity over UCH L3 (ubiquitin C terminal hydrolase L3). LDN 57444 can increase levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. It causes cell death through the apoptosis pathway. LDN 57444s activity leads to dramatic alterations in synaptic protein
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