The best-case scenario is that youve got a strong multicolored board already, and Guideline Station will just make that stronger
If you're looking to get big creatures on the board, or just really enjoyed Dune, this one might be worth a look for you
As you lose the Monarchy whenever you're damaged by an opponent's creature in combat, Spore Frog combined with Dawnglade Regent and Meren of Clan Nel Toth makes you unable to take combat damage (or rather, it does but that damage is prevented in full)
One of the things I love about casual EDH is that there is a lot of space for interesting, janky and even "bad" decks, provided you are playing in a group where the power level allows those suboptimal decks to actually have a game and do stuff
Infect will put a -1/-1 counter on a creature instead of dealing regular damage to it, and doing so will give you 1/1 token creatures that have deathtouch