Declaration in Stone, Stasis Snare, and Reflector Mage are off the table, mostly limiting options to Ob Nixilis Reignited, Planar Outburst, Tragic Arrogance, and back-door Collected Companies as common ways to remove this threat as of the current Standard format
Its worth noting that the deck already comes with a Thought Vessel, a ramp Artifact that also generates one colorless mana and removes your maximum hand size
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Features Blastoise, Pikachu, Charizard, and Venusaur on the cover
There are drawbacks to Hypergenesis as well, like needing to fill your deck with super-expensive cards that you aren't going to be able to cast fairly if your opponent can shut down your plan of cascading into Hypergenesis, which is a real risk in a format where Teferi, Time Raveler, Chalice of the Void, and Force of Negation are among the most played cards in the format