Now the only way an opponent could evade infect damage would be to always have a chunk blocker ready, exile Plague Myr, or enchant it with a Pacifism-type aura to prevent it from attacking and blocking
The Cycling Lands The cycling lands are one of the best anti flood lands I was discussing previously that Magic has
Spellslinger decks like Mizzix of the Izmagnus will appreciate the extra experience, and Niv-Mizzet, Parun will draw you extra cards on top of getting to reuse spells
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Further to that you do still ideally want an unthreatened life total, perhaps backed up with life gain, and both library synergy and manipulation effects