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Finding ways to enable this card will be key to Red strategies, but preventing life gain for the rest of an entire game is an absurdly powerful ability

Sequences where you attack with a 1-drop and follow it with this card will be good, and if you keep attacking, this red creature can generate more value

I like to play it with white cards that make tokens when I gain life, or alongside cards like Black Market and Life Insurance that can help to produce mana

You have to exile the legendary sorcery upon resolution, which is less fun since you cant bring it back to your hand to keep playing through some other means, but it is copyable by Shiko and Narset, Unified so you can get at least two turns in a row through it

Another nice little synergy is the interaction between Pain Seer and convoke