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Nyx Infusion was an example in the original Theros block, but I prefer more subtle cards with single effects which play out differently attached to opposing creatures

It can be a safe or locked drawer

Then the younger collectors who grew up with Ruby Sapphire will begin grading those cards as well because they're not as attracted to the older sets since that is not what they grew up with

Further to that you do still ideally want an unthreatened life total, perhaps backed up with life gain, and both library synergy and manipulation effects

7 Giratina VSTAR: Crown Zenith (Secret Rare) $199.88 Ruling A Dark Dimension There are dozens of gorgeous, valuable cards in Crown Zenith, but none can hold a candle to the value of its best chase card: the Giratina VSTAR secret rare