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Smiles: CCN1C(=O)C(=CC2=CN=C(NC3=CC(F)=C(C=C3)N3CCNCC3)N=C12)C1=CC=C(Cl)C=C1Cl
25(11):1349-52
Kobe2602 may serve as a scaffold for the development of Ras inhibitors with higher potency and specificity
Ethamsylate reduces the mean bleeding time when administered systemically or orally to rabbits
an IC50 of 84 μM in inhibition of the hERG potassium current
CNX-1351 - CAS# 1276105-89-5 Catalog No.:M9803-10 Smiles: CCN1C(=O)C(=CC2=CN=C(NC3=CC(F)=C(C=C3)N3CCNCC3)N=C12)C1=CC=C(Cl)C=C1ClCNX 1351 is a selective covalent Inhibitor of PI3K. In an end point assay, CNX 1351 potently inhibited PI3K and was 20400 times less potent against , , and . CNX 1351 inhibit PI3K signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX 1351 inhibits growth of cells dependent on PI3K. CNX 1351 also inhibits PI3K signaling in vivo and bonds to p110. Product information CAS Number: 1276105 89 5 Molecular
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