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EC50 ~120 nM)
Smiles: C[C@@H](OC)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1C1NC2=CC(F)=C(C=C2N=1)[C@H]1CC[C@H](C2C=C3N=C(NC3=CC=2F)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC)N1C1C=C(F)C(=C(F)C=1)N1CCC(CC1)C1C=CC(F)=CC=1
2MeSADP-induced inhibition of forskolin-stimulated adenylyl cyclase activity in P2Y12-C6-15 cells is unaffected by YM-254890 at 40 μM
dogs (3 mg/kg)
PubMed PMID: 18791063
Vinorelbine (ditartrate) Catalog No.:M9575-2 EC50 ~120 nM)Vinorelbine is a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with