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3-dihydropyridazine-4-carboxamides for the treatment of cancer
5-trifluorophenyl)methyl]carbamate
InChiKey: BNJOZDZCRHCODO-UHFFFAOYSA-N
which potently and selectively kills cells containing an MLL translocation
Ikarisoside-F
AMG 837 linide Calcium 3-dihydropyridazine-4-carboxamides for the treatment ofAMG 837 is a potent partial agonist of GPR40 (FFAR1) that is highly selective over GPR41, GPR43, and GPR120. GPR40 is a G protein coupled free fatty acid receptor localized mainly on pancreatic islet cells that activates the Gq signaling pathway. AMG 837 increases insulin release when glucose levels are elevated, but it failed to do so in healthy volunteers during Phase I clinical trials. Product information CAS Number: 865231 46 5 Molecular Weight:
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