CDK12-IN-E9 Size:Contact [email protected] for quotation Smiles: CO/N=C(/C1=CSC(N)=N1)\C(=O)N[C@H]1[C@H]2SCC(COC)=C(C(O)=O)N2C1=O

Smiles: CO/N=C(/C1=CSC(N)=N1)\C(=O)N[C@H]1[C@H]2SCC(COC)=C(C(O)=O)N2C1=O

Exposures (AUC) increases in a less than dose-proportional manner from 23 μM•h at 5 mg/kg to 362 μM•h at 500 mg/kg

InChiKey: HEGZERUHBVYZPH-UHFFFAOYSA-N

and increases in the number of ChAT-immunoreactive cells in the medial septum in Ab-treated rats to the levels of vehicle-injected control rats

KD =53±2 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets)

CDK12-IN-E9 Size:Contact [email protected] for quotation Smiles: CO/N=C(/C1=CSC(N)=N1)\C(=O)N[C@H]1[C@H]2SCC(COC)=C(C(O)=O)N2C1=OCDK12 IN E9 is a potent and selective covalent CDK12 inhibitor and a non covalent CDK9 inhibitor, while avoiding ABC transporter mediated efflux. CDK12 IN E9 has weak binding ability to CDK7 CyclinH complex with an IC50> 1 M. Product information CAS Number: 2020052 55 3 Molecular Weight: 434. 53 Formula: C24H30N6O2 Chemical Name: N [3 ({3 ethyl 5 [(2S) 2 (2 hydroxyethyl)piperidin 1 yl]pyrazolo[1,5 a]pyrimidin 7 yl}amino)phenyl]prop 2 enamide Smiles: