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Inhibitor of macrophage stimulation and interleukin-1 production
Expert Opin Investig Drugs
Formula: C19H14BrClN6O2
InChi: InChI=1S/C12H16ClNO3
Chemical Name: (Z)-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol
PF-543 citrate - CAS# 1415562-83-2 C-2036 Inhibitor of macrophage stimulation andPF 543 is a novel selective SK 1 inhibitor which inhibited SK 1 activity in a competitive manner with sphingosine. PF 543 inhibits SphK1 with a K(i) of 3. 6 nM, is sphingosine competitive and is more than 100 fold selective for SphK1 over the SphK2 isoform. PF 543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF 543 is the most
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