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18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8
25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner
Hu7691 free base has a significant inhibitory effect on the growth of 18 kinds of human tumor cells (U87-MG
Chemical Name: tetralithium(1+) ({[(2R
5'-tetrachloro-2'-(2-hydroxybenzoyl)-1'H-[1
APG-1387 l D6 Nitrate 18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8APG 1387, a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP 1, cIAP 2, and ML IAP). APG 1387 induces degradation of cIAP 1 and XIAP proteins, as well as caspase 3 activation and PARP cleavage, which leads to apoptosis. APG 1387 can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma. Product information CAS Number: 1570231 89 8 Molecular Weight: 1157.
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