MS023 - PRMT Inhibitor. CAS# 1831110-54-3 0331 reversible and selective inhibitor of

reversible and selective inhibitor of human USP14 with an IC50 of 4

Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains

delayed tumor growth in vivo

StemRegenin1 (SR1)

InChi: InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3

MS023 - PRMT Inhibitor. CAS# 1831110-54-3 0331 reversible and selective inhibitor ofMS023, CAS No. 1831110 54 3, is a potent, selective and cell permeable type I PRMT inhibitor (catalyzes mono and asymmetric dimethylation of arginine residues) with IC50 of 30 nM, 119 nM, 83 nM, 4 nM and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. It is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. A crystal structure of PRMT6 in complex with MS023 revealed that