Pay in 4 interest-free payments of $17.00 Learn more
Ships within 48 hours · Estimated delivery Oct 18 - Oct 23
SGI-1027 may have the potential for use in epigenetic cancer therapy
inhibits PI3Kα/δ/β with IC50 of 0
CUDC-907 induces apoptosis and G2–M cell-cycle arrest in cancer cells and effectively inhibits more than 50 different cancer cells’ growth
AZD2014 was orally dosed to mice at 2
InChiKey: AATMNHPDEZNXEK-UHFFFAOYSA-N
AK-7 - SIRT2 Inhibitor. CAS# 420831-40-9 size:2 mg solid SGI-1027 may have the potentialAK 7, CAS No. 420831 40 9, is a cell and brain permeable, selective sirtuin SIRT2 inhibitor (IC50 ~15. 5 M). AK 7 displays no effect on SIRT1 or SIRT3. It diminishes neuronal cell death induced by mutant huntingtin fragment. It also down regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. In two genetic mouse models of Huntingtons disease, AK 7 treatment resulted in improved motor function,