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TUG-891 - CAS# 1374516-07-0 size:2mg solid It stimulates the expression of

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Description

It stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells

1160/TH13-06-0484

Formula: C19H16N2O2

Hussain MD

7 (6)651-655

TUG-891 - CAS# 1374516-07-0 size:2mg solid It stimulates the expression ofTUG 891, CAS No. 1374516 07 0, is a potent and selective agonist of the free fatty acid receptor 4 (FFA4 GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG 891 also resulted in rapid phosphorylation and internalization of the receptor. TUG 891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo

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