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to distinguish the roles of GPER from those of ERα and ERβ in complex biological systems
Mezerein (50 μg/kg) shows significant inhibitory activity against the P-388 and L-1210 leukemias in mice
RS-8359 shows little affinity for the common central nervous system receptors and little anticholinergic effect
InChi: InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8
Valenzuela CA
Epidermal Growth Factor Receptor Peptide (985-996) Catalog No.:M23036-C to distinguish the roles ofEGFR (epidermal growth factor receptor) exists on the cell surface and is activated by the binding of its specific ligands, including epidermal growth factor and transforming growth factor . EGFR dimerization stimulates its intrinsic intracellular protein tyrosine kinase activity. As a result, autophosphorylation of several tyrosine (Y) residues on the C terminal domain of EGFR occurs. These include Y992, Y1045, Y1068, Y1148 and Y1173. This
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