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Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships
Solubility: DMSO : ≥ 50 mg/mL (57
IC50 > 30 μM)
CAS Number: 917-13-5
and suppression of ERK phosphorylation
RD162 ipine (hydrochloride) Neuroprotective coumarins from the rootIC50: 30. 9 nM RD162 is an androgen receptor (AR) antagonist. Metastatic prostate cancer is treated with drugs antagonizinf androgen action, but most patients progress to a more aggressive form of the disease named castration resistant prostate cancer, driven by elevated expression of the androgen receptor (AR). In vitro: RD162 was optimized from a screen for nonsteroidal antiandrogens retaining activity in the setting of increased androgen receptor