PROTAC Mcl1 degrader-1 exetil) shows greater than 50-100-fold selectivity

shows greater than 50-100-fold selectivity over other aspartyl proteases tested

(2013) J Am Chem Soc

Rupatadine is indicated for the treatment of allergic rhinitis and urticaria

MLN-9708 blocks BMSCs-induced MM cell proliferation

587871-26-9

PROTAC Mcl1 degrader-1 exetil) shows greater than 50-100-fold selectivityPROTAC Mcl1 degrader 1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl 1 inhibitor with an IC50 of 0. 78 M. PROTAC Mcl1 degrader 1 induces the ubiquitination and proteasomal degradation of Mcl 1 by introducing the E3 ligase cereblon (CRBN) binding ligand pomalidomide to Mcl 1 inhibitor S1 6 with M range affinity. Product information CAS Number: 2163793 38 0 Molecular Weight: 909. 84 Formula: C45H45BrN6O8S