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PubMed PMID: 19648907
2014 Aug 4
Molecular Weight: 244
0]oct-2-en-7-ylamino)-2-amino-6-oxohexanoate
H-1152 dihydrochloride
Ro 48-8071 viol PubMed PMID: 19648907Ro 48 8071 is an orally active cholesterol synthesis inhibitor or a 2,3 oxidosqualene: lanosterol cyclase (OSC) inhibitor. OSC (EC 5. 4. 99. 7) represents a unique target for a cholesterol lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG CoA reductase expression, generating a synergistic, self limited negative regulatory loop.
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