Pay in 4 interest-free payments of $8.00 Learn more
Ships within 48 hours · Estimated delivery Oct 20 - Oct 25
24)/t13-/m0/s1
Molecular Weight: 411
InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25
The X-ray co-crystal structures revealed the daminozide’s inhibition mode: it binds in the 2OG binding pocket and chelates to the active site metal via its acylhydrazide carbonyl and dimethylamino groups
PS48 was used at 5 µM concentration in cell culture
CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0216 24)/t13-/m0/s1CP 690550, CAS No. 477600 75 2, is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. It inhibits recombinant human JAK1 (IC50 ~ 3. 2 nM), JAK2 (IC50 ~4. 1 nM), and JAK3 (IC50 ~1. 6 nM). In cellular assays CP 690550 showed potent effects in the IL 2 blast proliferation assay (IC50 ~11 nM, mediated via JAK1 and JAK3) and HU03 cellular specificity assay (IC50 ~324 nM,