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is a potent inhibitor of BET bromodomains
CAS Number: 303-07-1
3 nM and the pA2=8
InChiKey: LNELWUPBSLZUIQ-MQMHXKEQSA-N
Braddock M
Itraconazole-d5 oxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside is a potent inhibitor ofItraconazole d5 (R51211 d5) is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14 demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Product information CAS
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