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[Epub ahead of print] PubMed PMID: 25987638
Smiles: CC1N=CSC=1C1C=CC(=CC=1)[C@H](C)NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCNC(=O)COC1=CC=CC=C1[C@@H](CCC1C=C(OC)C(=CC=1)OC)OC(=O)[C@@H]1CCCCN1C(=O)[C@@H](CC)C1=CC(OC)=C(OC)C(=C1)OC)C(C)(C)C
KG1 and NB4 cells with IC50 of 50 nM
Cilomilast (ED50 = 2
2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19
Olutasidenib (FT-2102) Size:2mg solid [Epub ahead of print] PubMedOlutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21. 1 nM, 114 nM for IDH1 R132H, IDH1 R132C, respectively. Product information CAS Number: 1887014 12 1 Molecular Weight: 354. 79 Formula: C18H15ClN4O2 Synonym: FT 2102 Chemical Name: 5 {[1 (6 chloro 2 oxo 1,2 dihydroquinolin 3 yl)ethyl]amino} 1 methyl 6 oxo 1,6 dihydropyridine 2 carbonitrile Smiles:
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