Larotrectinib sulfate 775riflophenone 3-C-glucoside TPI-1 selectively increases SHP-1 phospho-substrates

TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394

65(4):714-22

4-tetrazol-1-yl]methyl}pyridine hydrochloride

2017 Aug 8

InChiKey: LHHCSNFAOIFYRV-DOVBMPENSA-N

Larotrectinib sulfate 775riflophenone 3-C-glucoside TPI-1 selectively increases SHP-1 phospho-substratesLarotrectinib sulfate (LOXO 101 sulfate; ARRY 470 sulfate) is an ATP competitive oral, selective inhibitor of the tropomyosin related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). Product information CAS Number: 1223405 08 0 Molecular Weight: 526. 51 Formula: C21H24F2N6O6S Chemical Name: (3S) N {5 [(2R) 2 (2,5 difluorophenyl)pyrrolidin 1 yl]pyrazolo[1,5 a]pyrimidin 3 yl} 3