Pay in 4 interest-free payments of $30.00 Learn more
Ships within 48 hours · Estimated delivery Oct 16 - Oct 21
To correlate these in vivo responses with the molecular target of interest
Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers
and FGFR3 with IC50=~1 nM
MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex
Alantolactone induces apoptosis in HepG2 cells in a dose-dependent manner
A-966492 Size:2mg solid To correlate these in vivoA 966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP 1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A 966492 is orally bioavailable across multiple species, crosses the blood brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX 1 breast