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Formula: C27H34O11
1-dimethyl-2-oxo-N-(4-(trifluoromethyl)phenyl)-1
PubMed PMID: 11082439
InChiKey: FYSRKRZDBHOFAY-UHFFFAOYSA-N
COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1
SN-38 Size:Solid 2 mg Formula: C27H34O11SN 38 is the active metabolite of irinotecan (an analog of camptothecin a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be