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Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats
with selectivity >10-fold versus the inhibition of B cell proliferation
Smiles: CN([C@@H](CC1C=CC(=CC=1)OS(=O)(=O)C1=CC=CC2=CN=CC=C12)C(=O)N1CCN(CC1)C1C=CC=CC=1)S(=O)(=O)C1=CC=CC2=CN=CC=C12
Chemical Name: N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3
Su-11274 treatment significantly inhibits the migration of BaF3
VCP 171 KKε-IN-1(compound 1) Specnuezhenide Decreases Interleukin-1β-Induced Inflammation inAdenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5. 65, binding cooperativity with NECA 0. 68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve injury model of neuropathic pain. Product information CAS Number: 1018830 99 3 Molecular