CHMFL-PI3KD-317 Size:Contact [email protected] for quotation Smiles: CN1C=NC(CN2C=CC3C=CC(CNCC4NC5=CC=CC=C5C=4C4NC(=O)C5C=CC(O)=CC=54)=CC2=3)=C1

Smiles: CN1C=NC(CN2C=CC3C=CC(CNCC4NC5=CC=CC=C5C=4C4NC(=O)C5C=CC(O)=CC=54)=CC2=3)=C1

InChi: InChI=1S/C23H27N7O

Formula: C2H4N6

Pymetrozine is a feeding inhibitor of Homoptera

It also triggers DNA cleavage by topoisomerase II

CHMFL-PI3KD-317 Size:Contact [email protected] for quotation Smiles: CN1C=NC(CN2C=CC3C=CC(CNCC4NC5=CC=CC=C5C=4C4NC(=O)C5C=CC(O)=CC=54)=CC2=3)=C1CHMFL PI3KD 317 is a highly potent, selective and orally active PI3K inhibitor, with an IC50 of 6 nM, and exhibits over 10 1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3K (IC50, 62. 6 nM), PI3K (IC50, 284 nM), PI3K (IC50, 202. 7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882. 3 nM), VPS34 (IC50, 1801. 7 nM), PI4KIIIA (IC50, 574. 1 nM) and PI4KIIIB (IC50, 300. 2 nM). CHMFL PI3KD 317 inhibits PI3K mediated Akt