AZD8055 - mTOR Inhibitor. CAS# 1009298-09-2 size:2 mg solid Additional BAY-87-2243 application during RT

Additional BAY-87-2243 application during RT did not decrease TCD50

Formula: C17H11Cl3N2O3

SCH 503034

but not (R)-2-HG

Chemical Name: 4-ethyl-5-methyl-5

AZD8055 - mTOR Inhibitor. CAS# 1009298-09-2 size:2 mg solid Additional BAY-87-2243 application during RTAZD8055, CAS No. 1009298 09 2, is a highly potent, selective and ATP competitive mTOR inhibitor (IC50 = 0. 8 nM). It has >1, 000 fold selectivity against all PI3K isoforms (, , , ) and other members of the PI3K like kinase family (ATM and DNA PK). It has no significant activity against a panel of 260 kinases at concentrations up to 10 M. AZD8055 inhibits the phosphorylation of mTORC1 downstream targets (p70S6K and 4E BP1) as well as phosphorylation of