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HTH-01-015 inhibits NUAK1 with an IC50 of 100 nM
124(1):16-20
Like the parent compound
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells
even when Dizocilpine (MK-801) is applied for a long time in the presence of NMDA
IWR-1 - CAS# 1127442-82-3 60189 HTH-01-015 inhibits NUAK1 with anIWR 1, also known as IWR 1 endo, CAS No. 1127442 82 3, is a an inhibitor of the Wnt signaling cascade through inhibiting TNKSs, binding only to the adenosine binding site. IWR 1 inhibits epithelial mesenchymal transition of colorectal cancer cells through suppressing Wnt catenin signaling as well as survivin expression. IWR 1 inhibits cell proliferation and EMT even in the presence of TNF induced cancer cell stimulation. IWR 1 also significantly
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