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InChi: InChI=1S/C24H28N6O2/c1-16(2)30-15-27-21-22(25-13-17-5-9-19(31-3)10-6-17)28-24(29-23(21)30)26-14-18-7-11-20(32-4)12-8-18/h5-12
Tezosentan has no effect by itself on blood pressure in these pithed rats
also known as PMEA and GS-0393
it exhibits robust activity as well with GI50 of 0
Then compared to the vehicle
ATC 0065 cavir sulfate InChi: InChI=1S/C24H28N6O2/c1-16(2)30-15-27-21-22(25-13-17-5-9-19(31-3)10-6-17)28-24(29-23(21)30)26-14-18-7-11-20(32-4)12-8-18/h5-12ATC0065 is a selective and potent antagonist of the melanin concentrating hormone receptor 1 (MCH1) with IC50 of 15. 7 nM. This component also displays affinity for 5 HT1A and 5 HT2B receptors with IC50 of 62. 9nM and 266 nM respectively. Melanin concentrating hormone receptor (MCH1), a member of the G protein coupled receptor family 1, is an integral plasma membrane protein which binds melanin concentrating hormone. The protein can inhibit cAMP