ZX-29 Size:Contact [email protected] for quotation 3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]-3-carbamoylpropanamido]-3-methylpentanamido]-4-carbamoylbutanamido]-4-(methylsulfanyl)butanamido]-4-methylpentanamido]-4-methylpentanamido]-4-carboxybutanamido]propanamido]propanamido]-3-carboxypropanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-4-carboxybutanamido]-5-carbamimidamidopentanoic acid

3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]-3-carbamoylpropanamido]-3-methylpentanamido]-4-carbamoylbutanamido]-4-(methylsulfanyl)butanamido]-4-methylpentanamido]-4-methylpentanamido]-4-carboxybutanamido]propanamido]propanamido]-3-carboxypropanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-4-carboxybutanamido]-5-carbamimidamidopentanoic acid

9)6-4-2-1-3-5-6/h3-8

SW044248 shows no effect on Top2

example 19

Fancelli D

ZX-29 Size:Contact [email protected] for quotation 3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido]-3-carbamoylpropanamido]-3-methylpentanamido]-4-carbamoylbutanamido]-4-(methylsulfanyl)butanamido]-4-methylpentanamido]-4-methylpentanamido]-4-carboxybutanamido]propanamido]propanamido]-3-carboxypropanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-4-carboxybutanamido]-5-carbamimidamidopentanoic acidZX 29 is a potent and selective ALK inhibitor with an IC50 of 2. 1 nM, 1. 3 nM and 3. 9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX 29 is inactive against EGFR. ZX 29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX 29 also induces protective autophagy and has antitumor effect. Product information CAS Number: 2254805 62 2 Molecular Weight: 518. 03 Formula: