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or P-glycoprotein status
Abramochkin DV
thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs
MLN8237 is currently in Phase II study for treatment of patients with ovarian
CAS Number: 879085-55-9
TH-237A hexiline Maleate or P-glycoprotein statusTH 237A is a novel neuroprotective agent, which possess protective properties against amyloid (A) induced neurodegeneration associated with Alzheimer's disease. Exposure of neuronal cultures to A peptide in the presence of 5 nM TH 237A resulted in a 50% increase in survival. Neuronal cultures treated with other toxic stimuli such as staurosporine, thapsigargin, paraquat and H2O2 showed significantly enhanced survival in the presence of TH 237A .