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Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion
Smiles: COC1=CC(=CC=C1O)C1CC(=O)C2=C(C=C(C=C2O)OC2OC(CO)C(O)C(O)C2OC2OCC(O)(CO)C2O)O1
In a drug resistant GE1 strain
38-log CFU reductions
Exp Eye Res
Mutant IDH1-IN-4 terhydrate Bafilomycin A1 disrupts autophagic fluxMutant IDH1 IN 4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of 0. 5 M for mutant IDH1 in R132H, HT1080 and U87R132H cells. Product information CAS Number: 1416270 18 2 Molecular Weight: 438. 56 Formula: C25H34N4O3 Chemical Name: 8 cyclopropyl 6 [(3R) 3 cyclopropyl 4 (3 methoxypropanoyl)piperazin 1 yl] 3,3 dimethyl 1H,3H,4H pyrano[3,4 c]pyridine 5 carbonitrile Smiles:
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