SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-10S Sanders MA

Sanders MA

ABT-888 dihydrochloride enhances apoptosis and autophagy in response to treatments that cause DNA breaks

27(1):293-8

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3-fold left shift of the glutamate CRC) at mGlu6 and antagonist activity (3

SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-10S Sanders MASR9009, CAS No. 1379686 30 2, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~670 nM and REV ERB with EC50 ~800 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9009 alters circadian behavior and the circadian pattern of core clock