AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 1'-biphenyl]-4-yl)methyl)benzenesulfonamide

1'-biphenyl]-4-yl)methyl)benzenesulfonamide

AGI-5198 has good cellular activities in TS603 glioma cell line

Formula: C17H18N6

and 2-HG production in HT1080 and U87MG cells with IC50 < 0

but activates only the α7 to any significant extent

AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 1'-biphenyl]-4-yl)methyl)benzenesulfonamideAZD6244, CAS No. 606143 52 6, (Selumetinib, ARRY 142886) is an orally active, highly potent and selective non ATP competitive MEK inhibitor, inhibiting MEK1 with an IC50 of 14 nM. In vitro cell viability inhibition screening of a tumor cell line panel found that cell lines harboring BRAF or RAS mutations were more likely to be sensitive to AZD6244. Treatment of primary HCC cells with AZD6244 led to growth inhibition, caspase 3 and caspase 7