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LB-100 Catalog No.:M8527-10 183320-51-6 (Desmethyl Erlotinib hydrochloride)

SKU: 58397919093

4.7
USD90.00 USD117.00

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Description

183320-51-6 (Desmethyl Erlotinib hydrochloride)

(-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins

Poeschke O

Smiles: CC1C=C(C=C(C)C=1CC1=CC=C(O)C(=C1)C(C)C)OCP(O)(O)=O

compound list : BAY-87-2243

LB-100 Catalog No.:M8527-10 183320-51-6 (Desmethyl Erlotinib hydrochloride)LB 100 is a protein phosphatase 2A(PP2A)inhibitor. LB 100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. LB 100 enhanced the effects of sorafenib in HCC cells only during hypoxic environments. LB 100 dramatically increased intracellular p Smad3 level, which was responsible for the effect of LB 100 as a sensitizer. LB 100 downregulated Bcl 2 expression and enhanced sorafenib

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