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PubMed PMID: 25241015
36(12):2541-50
Garcia-Saez I
Smiles: CC1C=CC(=CC=1)NC1=CC(=O)C2SC(C)=NC=2C1=O
33)20-13(24)7-5-8-14(20)25/h4-11
Varenicline - CAS# 249296-44-4 60026 PubMed PMID: 25241015Varenicline, CAS No. 249296 44 4, is a nicotinic receptor partial agonistit stimulates nicotine receptors more weakly than nicotine itself does. In this respect it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement therapies (NRTs) like nicotine patches and nicotine gum. Varenicline displays full agonism on 7 nicotinic acetylcholine receptors and is a partial agonist on the 42, 34, and 62 subtypes.
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