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ML224 could be a useful tool for studying TSHR functions
Chemical Name: 1-(isoquinolin-6-yl)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)urea
Bryan King
Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively
Formula: C26H26F3N3O3
GSK-2981278 - CAS# 1474110-21-8 Catalog No.:M6485-10 ML224 could be a usefulGSK 2981278, CAS No. 1474110 21 8, is a highly potent and selective inverse agonist of retinoic acid receptor related orphan receptor gamma (ROR gamma). GSK 2981278 is a strong ROR selective inverse agonist that inhibits activation of the il17 promoter. GSK 2981278 robustly inhibits ROR mediated cytokine production at both the mRNA and protein level. GSK 2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK 2981278
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