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InChi: InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28
[Epub ahead of print] PubMed PMID: 30031170
is a highly potent tubulin inhibitor
Formula: C18H14Cl2FN3
5 nM for human PD-1/PD-L1 interaction
CJ-42794 Catalog No.:M20871-C InChi: InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28CJ 42794 is a selective prostaglandin E receptor subtype 4(EP4) antagonist, inhibits [3H] PGE2 binding to the human EP4 receptor with a mean pKi of 8. 5, a binding affinity that was at least 200 fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3). IC50 value: 8. 5 (pKi ) Target: EP4in vitro: CJ 042794 competitively inhibits PGE2 evoked elevations of intracellular cAMP levels in HEK293 cells
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