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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
26(5):1149-56
AG-490 (100 μM) inhibits Akt phosphorylation
Discovery of L-755
Voxelotor shows T1/2s of 11
PROTAC CRABP-II Degrader-3 Catalog No.:M8008-10 Smoothened mutation confers resistance toPROTAC CRABP II Degrader 3 is a potent cellular retinoic acid binding protein (CRABP II) degrader based on cIAp1. Product information CAS Number: 1225383 41 4 Molecular Weight: 853. 05 Formula: C46H68N4O11 Chemical Name: (2E, 4E, 6E, 8E) 9 ((E) 3 ((17S, 20S, 21R) 21 amino 20 hydroxy 17 isobutyl 2, 16, 19 trioxo 22 phenyl 6, 9, 12, 15 tetraoxa 3, 18 diazadocosyloxyimino) 2, 6, 6 trimethylcyclohex 1 enyl) 3, 7 dimethylnona 2, 4, 6, 8 tetraenoic acid
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