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Effects of RWJ 67657
Toxicol Sci
2533/chimia
1996 Jan 5
Cocktail Formulation: 5 mM Thiazovivin
GSK-2606414 - CAS# 1337531-36-8 0435 Effects of RWJ 67657GSK 2606414, CAS No. 1337531 36 8, is an orally available, potent, and selective PERK inhibitor. GSK 2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR) like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival
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