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which reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice
InChi: InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H
PubMed PMID: 18624980
and c-Myc)
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
E-7449 - CAS# 1140964-99-3 0290 which reverses MK-801-induced impairment inE 7449, also known as 2X 121, CAS No. 1140964 99 3, is an orally available small molecule inhibitor of the nuclear enzymes poly (ADP ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E 7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes
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