Nicotinamide N-oxide O-amido-C4-N3 E6005) is a selective phosphodiesterase

E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2

) exhibits terminal elimination half-lives (rat 8

SR-3029 (20 mg/kg daily i

Formula: C39H52N12O12

3-dioxoisoindolin-4-yl)oxy)pentanoic acid

Nicotinamide N-oxide O-amido-C4-N3 E6005) is a selective phosphodiesteraseNicotinamide N oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor. Human Endogenous Metabolite Nicotinamide is one of the forms of vitamin B3. It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the