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which reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice
When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target is inhibited >50% (PDE3
Liverani E
GSK 2251052
Schwartz TW
CERC-501 - CAS# 1174130-61-0 60224 which reverses MK-801-induced impairment inCERC 501, also known as JNJ 67953964, LY 2456302 and Aticaprant, CAS No. 1174130 61 0, is a potent, selective, short acting antagonist of the opioid receptor (KOR) (Ki = 0. 81 nM vs. 24. 0 nM and 155 nM for the opioid receptor (MOR) and opioid receptor (DOR). Aticaprant is under development for the treatment of major depressive disorder and substance use disorders including alcoholism, nicotine addiction, and illicit drug dependence. Aticaprant has
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