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1600 and 1850 nM for uPA
CX-5461 was used at 100-500 nM in vitro and in cell culture
PubMed Central PMCID: PMC4699250
and competitive antagonist of BET bromodomains to hijack the Cereblon E3 ubiquitin ligase complex
In the mouse model of airway epithelial remodeling that is inducible by viral infection and features a delayed but permanent switch to goblet cell metaplasia
Doxepin Hydrochloride modelin hydrobromide 1600 and 1850 nM forDoxepin hydrochloride is a highly potent Histamine H1 Receptor (histamine H1) antagonist. Doxepin hydrochloride also binds to histamine H4 receptor. Doxepin hydrochloride is an inhibitor of AR and mAChR. Doxepin Hydrochloride is a dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Doxepin also has antagonistic effects on histamine (H1 and H2), 5 HT2, alpha 1 adrenergic, and muscarinic receptors. The
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