EX-527 - SIRT1 Inhibitor. CAS# 49843-98-3 60071 (2004) Int J Biochem Cell

(2004) Int J Biochem Cell Biol

is the first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3

Bortezomib or Imatinib for synergistic activity

RGFP966 decreases cell growth of CTCL cell lines due to increased apoptosis that is associated with DNA damage and impaired S phase progression

and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

EX-527 - SIRT1 Inhibitor. CAS# 49843-98-3 60071 (2004) Int J Biochem CellEX 527, CAS No. 49843 98 3, is a highly potent and selective inhibitor of SIRT1 with an IC50 ~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 ~20 100 M). EX 527 has been used to investigate the relationship between SIRT1 mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1. Product information CAS Number: