PI3Kdelta inhibitor 1 ro-2-(4-methoxyphenyl)-4-oxo-1 5-benzothiazepin-5(2H)-yl]ethyl]methyl-d3-carbamic Acid 1-Chloroethyl Ester B-Raf IN 1 (Compound 10n)

B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0

Smiles: CC1(C)CC(=O)C=C(C)[C@]1(O)/C=C/C(/C)=C\C(=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

C6H14N2O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15

BrH/c1-4-5-9-16-15(11-12-18(2)3)13-14-8-6-7-10-17(14)16

InChi: InChI=1S/C23H30N4O6/c24-12-5-3-1-2-4-6-13-25-19(29)14-33-17-9-7-8-15-20(17)23(32)27(22(15)31)16-10-11-18(28)26-21(16)30/h7-9

PI3Kdelta inhibitor 1 ro-2-(4-methoxyphenyl)-4-oxo-1 5-benzothiazepin-5(2H)-yl]ethyl]methyl-d3-carbamic Acid 1-Chloroethyl Ester B-Raf IN 1 (Compound 10n)PI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3K inhibitor with an IC50 of 1. 3 nM. Product information CAS Number: 2242109 74 4 Molecular Weight: 558. 69 Formula: C27H38N6O5S Chemical Name: N [2 methoxy 5 (1 methyl 4 {[(3R) 1 [2 (oxan 4 yl)ethyl]piperidin 3 yl]methoxy} 1H pyrazolo[3,4 b]pyridin 6 yl)pyridin 3 yl]methanesulfonamide Smiles: CN1N=CC2=C1N=C(C=C2OC[C@H]1CN(CCC1)CCC1CCOCC1)C1C=C(NS(C)(=O)=O)C(=NC=1)OC