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4)5)12-21(20)36-23/h7-8
(2002) Genes Dev
MLK1 and Zap70
embryonic kidney cyst model
Epub 2014 Apr 23
Bicyclol ioguanine 4)5)12-21(20)36-23/h7-8Bicyclol, also known as SY 801, is a hepatoprotective agent. Bicyclol upregulates transcription factor Nrf2, HO 1 expression and protects rat brains against focal ischemia. Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K AKT and Ras Raf MEK ERK pathways. Bicyclol attenuates tetracycline induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. Bicyclol
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