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TUG-770 shows excellent stability toward human liver microsomes (HLM)
Cardamonin inhibits activation of the NF-κB pathway
H2O/c23-19(22-9-7-21(8-10-22)18-5-6-18)17-3-1-16(2-4-17)15-20-11-13-24-14-12-20
TBPB is a bitopic ligand
PubMed Central PMCID: PMC3771970
LXR-623 epridil HCl TUG-770 shows excellent stability towardLXR623, also known as WAY 252623, is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR( ) atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY 252623 significantly reduced total (50 55%) and LDL cholesterol (LDLc) (70 77%) in a time and dose