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can be used as a cytotoxic component of antibody-drug conjugates (ADCs)
Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen
4S)-4-(17-amino-3
119 and 434 nM
including those of brain
DC0-NH2 e olamine can be used as aDC0 NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0 NH2 is about 1000 fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0 NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component. Product information CAS Number: 615538 51 7 Molecular Weight: 550. 01 Formula: C31H24ClN5O3 Chemical Name: 5 amino N {2 [(1S) 1
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